I bought Julie this game for her birthday (insert husband-buying-wife-gift-that's-really-for-him joke here), and man oh man, it is a helluva great game.
For those that don't know, the game is a campaign-style version of the classic Pandemic. You go month to month with an ongoing storyline, and the game itself gets affected by the decisions and results of each previous game. Objectives change, new rules are added, and even the board gets changed permanently. Julie and I are currently 6-3 in the game, and the board is all kinds of different and TONS of new game elements and rules have been added.
The game does get a little tedious - there is a LOT to remember as you get further and further in. We are about to start July, I believe, and it has been a blast. We've won some months by the skin of our teeth. It's crazy strategic, and also lots of fun. Just wanted to throw out a recommendation to my gaming friends. You can also play it solo too, in case your wife/gf doesn't do games :)